Newsletter | November 24, 2025

11.24.25 -- Sensitive Critical Starting Materials Need A 'Just-In-Data' Approach

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The push to lower biomanufacturing costs necessitates an increased focus on process efficiency and flexibility. Using perfusion technology in upstream processes can boost productivity and reduce costs compared to traditional methods. By maintaining high cell densities during cell expansion, perfusion minimizes equipment use, time, and resources while also lowering risks. Discover how intensified solutions can help reduce process steps, efficiently utilize facility space, and mitigate risk while maintaining high product quality in this technical article.

FOCUS ON UPSTREAM MANUFACTURING

Sensitive Critical Starting Materials Need A 'Just-In-Data' Approach

Here's a blueprint for transforming the fragmented, high-risk interface between vector and cell therapy platforms into a unified, predictable, and compliant system.

Predicting The Performance Of Perfusion Media In A Continuous Bioreactor

Small-scale perfusion-mimic models can effectively predict media performance in continuous bioreactors to help optimize cell density, productivity, and scalability for CHO cell lines.

Revolutionizing Cell Metabolism Monitoring

Unlock real-time insights into cell health and productivity with continuous glucose and lactate monitoring. Discover how an innovative technology is transforming bioprocessing and research.

Break Manufacturing Bottlenecks With Day-0 Transduction, Day-3 Harvest

Discover the potential of T1 cell-derived nanoparticles (CDNPs) to accelerate T-cell activation. See how CDNPs’ unique mechanism of mimicking physiological immune stimulation positions them for broad use.

What Is Transfection?

Learn about the process of transfection and why it is crucial for studying gene function and has applications in various fields, including drug development and gene therapy.

High-Yield Expression Of Complex Proteins From Stable Pools

This study presents the development of apoptosis-resistant CHO cell lines (DKO1 and DKO2), using electroporation technology, with the goal of enhancing biotherapeutic production.

Systematic Approach to Enhancing iPSC Expansion

Discover how to optimize iPSC culture conditions for significant cell number increases while preserving stem cell features.

Expansion Of Cord Blood-Derived CD34+ Cells In A Hollow-Fiber Bioreactor

CD34+ cells isolated from cord blood were expanded in a hollow-fiber bioreactor using a novel cytokine cocktail at one-tenth the standard concentration using a MSC-free coating strategy.

Overcoming Common Challenges In Microbial Fermentation Scale-Up

Successful microbial scale-up hinges on ensuring process consistency, optimizing yield, and simplifying compliance. Learn strategies to overcome key challenges in bacterial, fungal, or yeast fermentation.

UPSTREAM MANUFACTURING SOLUTIONS

Stop Compromising Between Yield And Glycosylation Quality - Roche CustomBiotech

Your New Control Center For Cell Therapy Process Development - PBS Biotech, Inc.

Centrifuge Bioprocess Bags - Entegris, Inc.

Choose The Rapid Methods Package For Your CHO Bulk Harvest Testing - MilliporeSigma

PharmaLok ZerO Sanitary Clamps - Nordson MEDICAL

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