Application Note

High-Yield Expression Of Complex Proteins From Stable Pools Generated By MaxCyte® Electroporation

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Researchers created apoptosis-resistant CHO cell lines (DKO1 and DKO2) with the goal of enhancing biotherapeutic production. These Bax/Bak double knockout CHO cells were used to create bulk pools expressing complex biologics with peak titers exceeding 8 g/L. The bulk pool generation process utilized MaxCyte® electroporation for the high-efficiency, high-viability transfection of custom CHO cells, enabling high-density, extended-duration production cultures. These high-viability cultures can deliver cost savings

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