Newsletter | August 26, 2024

08.26.24 -- Report: Single-use Bioreactor Uptake Plateaued, Other SUT On The Rise

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Webinar: Bringing It All Together – Data Harmony in the Bioprocess Ecosystem

Join us on September 20th to learn how to achieve seamless data integration within your bioreactor system by unifying information from various sources to gain a holistic view of your cultivation process. Discover how to contextualize bioreactor data using cutting-edge tools to create valuable insights about your cultivation and embrace automation methodologies to free up resources for critical decision-making.

FOCUS ON UPSTREAM MANUFACTURING

Report: Single-use Bioreactor Uptake Plateaued, Other SUT On The Rise

BioPlan Associates' latest manufacturing survey found signs of a maturing market and strong demand for innovation upstream and downstream.

Optimized Cell Culture Medium For Scalable Viral Vector Production

Examine a new cell culture medium which offers an improved alternative to classical formulations that can help address the constraints in viral vector manufacturing and scale-up.

Robust CHO Cell Expression Platform For High-Quality Biomanufacturing

Rapid development of high-quality cell lines is vital to biomanufacturing projects. How developers approach the fundamental steps can define their core biologics capabilities and keep projects on track.

Engineering CHO K1 Cells With Three Orthogonal Transposase Systems

Transposase-mediated genome engineering enables the robust and stable relocation of discrete DNA segments (transposons) in the genome, providing a valuable tool for stable transgene expression.

Achieve Fast And Efficient Isolation Of Exosomes From Stem Cells

Review this demonstration of a bioreactor and bioreactor system combination used to isolate exosomes after culturing human adipose-derived stem cells in suspension on microcarriers.

Using 250mL Bioreactors For AAV Production

This demonstration examines an AAV upstream process in proprietary bioreactors, including an example of using process optimization to increase the fraction of full AAV capsids.

CHO Media Screening Success Using Benchmarking Studies

Explore the challenges of media screening and a straightforward approach for saving time, reducing risks, and improving outcomes.

Better Media, Better Outcomes

As the cell therapy industry experiences rapid growth, media and reagents present a valuable opportunity to meet future therapeutic needs.

Considerations For Developing The Recirculation/Perfusion Process

Learn about the recirculation and perfusion processes made possible by single-use, fixed-bed bioreactors designed for scaling up adherent cell culture processes.

Preparing For An Imminent Transformation In How We Treat Diseases

Review practical considerations for implementing NAT-based methods, where concrete recommendations are necessary, and how guidelines can remain relevant for new medicinal products.

Advancing Precision Medicine With Patient-On-A-Chip

Emulate and Cedars-Sinai Medical Center have partnered to develop a Patient-on-a-Chip program that combines their stem cell expertise and Organs-on-Chips technology to advance precision medicine.

Support The Culture Of Adherent Vero Cells With A Serum-Free Medium

This study compares a serum-free medium to other commercially available pre-hydrated media to measure its effectiveness in supporting the culture of adherent Vero cells.

Enabling Rapid, High-Yielding, Stable Cell Line Development

Discover how to simplify and accelerate CHO-S stable cell line development, eliminating the need for extensive screening of candidate clones and specialized equipment.

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AI and machine learning are the buzzwords of the decade, often accompanied by lofty promises — but what do they really mean for biopharma? How can these technologies be adopted to improve biomanufacturing processes, testing, and quality? Join Bioprocess Online Live for an exploration into the practical applications of AI/ML in biomanufacturing, its barriers to adoption, and how regulators can help standardize use across the industry. Registration is free thanks to the support of Atum Bio.

UPSTREAM MANUFACTURING SOLUTIONS

OsmoTECH HT Automated Micro-Osmometer - Advanced Instruments, Inc.

Single-Use Mixing Systems For Large-Scale Applications - Cytiva

Techfors-S Pilot Bioreactor - INFORS HT

Medium For Producing High AAV Titers In Multiple HEK293 Cell Lines - MilliporeSigma

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Webinar: Perfecting HEK293 Cells for Gene Therapy: The Role of Incubator Flexibility

Join us on September 23rd where we will focus on the development of a highly adaptable cell culture system that optimizes viral vector production using HEK 293 cells in shake flasks within a sophisticated multi-cabinet incubator. Learn how multi-cabinet incubators with adjustable parameters can optimize cell culture conditions and explore the methods used to achieve optimal conditions for viral production.

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Webinar: Formula Considerations for the Development of High Concentration Biopharmaceuticals

In the pursuit of attaining higher-concentration drug products several obstacles arise. These challenges include increased aggregation, formation of subvisible particles, and viscosity as well as process development challenges, such as Donnan Effects. This webinar will explore the fundamental formulation principles, strategies, and tools for producing successful high-concentration formulations including small scale tangential flow filtration to understand pH shifts. Click here to learn more

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