Robust CHO Cell Expression Platform For High-Quality Biomanufacturing

By Dr. Wen-Rong Jiang, Senior Director, Cell Line and Analytical Development, JOINN Biologics

Rapid development of a high-quality cell line is vital to any biomanufacturing project, but some of the industry’s most commonly used processes may be inadequate to help companies meet their timelines. The fundamental steps of cell line development have not changed, but how developers approach them can define their core biologics capabilities. Whether companies are considering upgrades to their in-house processes or seeking the assistance of a CDMO to develop their cell line, familiarity with some of the newer and more advanced techniques and technologies is essential.

A recent webinar discussed ways to streamline many of the standard steps involved with manufacturing a CHO cell line, from assessing the potential of candidates at the discovery stage all the way to stabilization. Experiments conducted in commercial laboratories show that these options are not only viable but also proven to save time and money while yielding higher-quality products.