Newsletter | May 27, 2025

05.27.25 -- Proper Care And Handling Of Coupons Used For Swab And Rinse Recovery Studies For Total Organic Carbon Analysis

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Future-Proof Your Process

Mobius® iFlex Bioreactors for upstream processes are a scalable portfolio of stirred tank bioreactors that leverage single-use bags with enhanced strength, made with our innovative Ultimus® film. Perfusion applications are supported with ease by integrating a perfusion tower, that uses the Cellicon® Filter Assemblies to retain cells in the bioreactor vessel while removing spent media. Future-proof your process with modular flexibility, and request a demo or technical consultation with our experts today!

FOCUS ON UPSTREAM MANUFACTURING

Proper Care And Handling Of Coupons Used For Swab And Rinse Recovery Studies For Total Organic Carbon Analysis

Surrogate surfaces, or “coupons”, are used to simulate pharmaceutical manufacturing surfaces or medical devices for the performance of swab and rinse recovery studies. Experts from The Center for Pharmaceutical Cleaning Innovation provide insights for proper care and handling.

Developing A Scalable Protocol For T Cell Activation, Expansion

Explore a scalable protocol for T cell activation and expansion, designed to enhance immunotherapy workflows. This approach ensures robust T cell growth, viability, and memory phenotypes for clinical applications. 

A Comparison Of Commercial Transfection Reagents In HEK 293 Cells

This study presents a detailed comparative analysis of the efficiency, viability, and cytotoxic effects of four widely used transfection reagents on Human Embryonic Kidney 293 (HEK293) cells.

Physiologix Serum Replacement Performance On Mesenchymal Stem Cells

Learn about the effectiveness of a xeno-free serum replacement in mesenchymal stem cell (MSC) culture and its potential to enhance cell growth and reduce variability compared to fetal bovine serum.

Simplifying CHO Cell Line Genetic Stability Testing

Here, we describe the use of whole genome sequencing to perform a comprehensive assessment of genetic stability in clonally derived CHO cell banks using the Aptegra™ CHO genetic stability assay.

Simplified LV, AAV Clarification With TFDF-Based Intensified Virus Production

Learn how Tangential Flow Depth Filtration (TFDF) enhances viral vector production, streamlining the clarification process and increasing efficiency and yield for LV and AAV manufacturing.

History Of The Multitron Incubator Shaker

Learn more about the history of an incubator shaker developed in 1930 and the journey it has taken into the modern era.

Scalable Manufacturing Using A GMP-Compatible Electroporation Platform

Genome editing with virus-like particles (VLPs) shows promise for gene therapy. Using electroporation, researchers achieved high VLP yields, and genome editing, advancing therapeutic applications.

Considerations For Developing The Recirculation/Perfusion Process

Learn about the recirculation and perfusion processes made possible by single-use, fixed-bed bioreactors designed for scaling up adherent cell culture processes.

Choosing The Most Effective Transfection Reagent For Your Needs

Choosing the right transfection reagent can be confusing. This guide explores product names, their applications, and the importance of testing beyond labeled uses.

Optimized Performance And Fast Bioreactor Setup

These single-use bioreactors can make life in the lab easier with an easy setup, workflow, and 3D printing technology that allows you to customize the bioreactor to your application.

Achieving Rapid, High-Titer Expression For Next-Generation Biologics

This advanced cell line development technology overcomes production challenges related to the expression and scalability of complex biologics.

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Webinar: Peptones and Vaccines: A Synergistic Approach to Enhanced Production and Efficiency

Discover how peptones can enhance vaccine production efficiency in this Thermo Fisher Scientific webinar. Learn how these versatile, cost-effective supplements support cell growth, viral production, and overall performance while reducing costs. Explore real-world data showcasing productivity gains and gain strategies for integrating peptones into your vaccine workflow to streamline development and accelerate market readiness. Click here to learn more.

UPSTREAM MANUFACTURING SOLUTIONS

Breakthrough Gentle Cell Separations Technology - CARR Biosystems

Advanced Tubing Retainers: Pharma+ - Nordson MEDICAL

Cell Culture Media & Supplements - RoosterBio

Integrated Biotech Services: From Strain To Commercial Product - Lonza

Cell Therapy - Pushing The Limit - BD Biosciences

Ascent Fixed Bed Reactor System 100 - Corning Life Sciences

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Webinar: How To Optimize Your Advanced Therapy Manufacturing Process Before You Automate

In the biopharmaceutical sector transformative therapies for rare or ultra-rare diseases and curative medicines are seen as extremely risky for investors and developers. Learn how phase-appropriate tools and strategic collaboration can reduce costs, improve scalability, and avoid locking in inefficient processes—without major capital investment. Topics include cryopreservation, separation, and scalable solutions from RUO to cGMP. Click here to learn more.

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