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| The body as a bioreactor | What if therapeutic production could move from the facility into the patient? Explore how advances in lipid nanoparticle design, delivery science, and manufacturing are helping bring the body-as-a-bioreactor vision closer to reality—and reshaping what may be possible for genomic medicine. |
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FOCUS ON UPSTREAM MANUFACTURING |
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By Bioprocess Online Live | In this segment from the Bioprocess Online Live event, “The Levers And Tradeoffs That Drive Process Productivity,” panelists David Scherr, Ph.D. (AstraZeneca) and Vadim Klyushnichenko, Ph.D. (Calibr-Skaggs), discuss how the process-related associated with next-generation molecules like bispecifics and trispecifics complicate downstream purification efforts impurities (e.g., chain mispairings). They agree that mitigating these impurities is a developmental challenge both upstream and downstream. | |
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| A Comprehensive Solution For Adventitious Agent Testing | White Paper | MilliporeSigma | Modern sequencing methods offer sensitive detection of adventitious and species‑specific viruses. Learn how targeted and non‑targeted NGS approaches improve confidence in cell bank characterization. |
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| Extracellular Vesicle Isolation From Conditioned Media | Poster | By Elie Zakhem, et al., RoosterBio and Lauren Torres, et al., Repligen | Explore a scalable, sterile solution for isolating extracellular vesicles (EVs) in exosome therapeutics to enhance yield, purity, and commercial viability through innovative filtration technology. |
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| Enabling 2-4x EV Yield Improvements In Bioreactor Culture | Poster | By Terri Willstaedt, Amy Walde, Elie Zakhem, Ph.D., and Jon A. Rowley, Ph.D., RoosterBio | A chemically defined fed-batch bioprocess medium simplifies hMSC-EV production, increasing yields while maintaining EV quality across donors and tissue types in scalable GMP-compatible environments. |
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| Beyond High Titers: Expanding A Generalized Host Engineering Tool | Poster | By Varsha Sitaraman, Renee Saville, Mario Pereira, et al., ATUM | Sequential genetic integration can equip stable cell lines with multiple functions. Uncover applications spanning antibody production, glycosylation control, receptor knockdown, and lentiviral packaging. |
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| A Hub For Life Sciences Drug Development | Article | By Sandy Castor, Middlesex County, NJ | Middlesex County, NJ, is a hotbed for the life sciences, offering a deep talent pool, an extensive R&D presence, and dedicated backing by local government in the form of strategic investment. |
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| Overcoming Regulatory Hurdles In AAV Production | Webinar | Mirus Bio | Demonstrating residual reagent clearance is a critical regulatory requirement in AAV manufacturing. Examine how specialized assays and strategic partnerships streamline compliance. |
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| Media And Buffer Mixing Using A Magnetic Mixer | Application Note | Cytiva | A common requirement for media and buffer preparation in biopharma processing is powder-liquid mixing. Review the performance of a 3000 L single-use mixing system for preparing aqueous solutions. |
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UPSTREAM MANUFACTURING SOLUTIONS |
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| Webinar: Maintaining Process Consistency and Performance During N-1 Perfusion Scale-Up | Scaling an intensified N-1 perfusion process from bench to pilot scale can present challenges. Drawing on collaborative work conducted across 5 L, 50 L, and 500 L bioreactor scales, experts will share how consistent culture performance, cell growth, and monoclonal antibody production were maintained throughout scale-up. Gain practical insights into the key considerations, challenges, and strategies for successfully transferring intensified upstream processes toward larger-scale manufacturing. |
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| Webinar: Scaling ADC manufacturing without compromising quality | Scaling ADC programs from clinical to commercial manufacturing brings new challenges in mixing, solvent distribution, hydrophobicity, and process control. This webinar explores practical strategies and digital tools to reduce scale-up risk, including CFD modeling for conjugation, membrane strategies for TFF, and SIMCA®-online for multivariate process control, batch genealogy, and golden batch monitoring. Discover approaches to improve consistency, robustness, and efficiency across ADC manufacturing. Click here to learn more. |
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