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| A Single-Use, Scale-Down, Predictive Solution For Intensified Perfusion Development | Perfusion is becoming a typical approach to achieving upstream process intensification. The ability to scale down these processes, however, has been limited due to lack of appropriate technologies. This webinar describes a new microbioreactor system that fulfills the throughput-performance gap providing single-use, perfusion bioreactors with 2mL working volume that can replicate bench scale perfusion processes at industrially relevant cell densities. Watch now. |
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FOCUS ON UPSTREAM MANUFACTURING |
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A conversation with Chris Stevens, Spark Therapeutics | The company proved the concept by bringing to market its AAV-based gene therapy for an inherited form of vision loss. |
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| Advances In High-Throughput Upstream Process Development | e-book | By Frank Agbogbo, Ph.D., Pawel Linke, Markus Neubauer, Ph.D., Brandy Sargent, Patricia McNeill, and Tim Noetzel, Ph.D., Roche CustomBiotech | Explore temperature effects on product titer, automated cell culture development workflow, maximizing product life-cycle efficiency with the right DOE strategy, and effective data management. |
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| Bioprocess Scale-Up: From Classrooms To Pilot Production | Article | By Joo Shun TAN (陈裕声), Universiti Sains Malaysia, INFORS HT | In this article, the author, an Associate Professor at Universiti Sains Malaysia, shares their positive experience using two specialized benchtop bioreactors to enhance bioprocess education and research. |
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| Highly Efficient Production Of Adeno-Associated Virus | Application Note | By Yulong Hong, Lori E. Romeo, Ann M. Ferrie, Vasiliy N. Goral, and Jennifer L. Weber, Corning Life Sciences | This study evaluates the performance of a flexible, automated fixed bed reactor (FBR) system during AAV production, comparing it with a similar FBR system and 2D cell culture controls. |
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| Webinar: Perfecting HEK293 Cells for Gene Therapy: The Role of Incubator Flexibility | Join us on September 23rd where we will focus on the development of a highly adaptable cell culture system that optimizes viral vector production using HEK 293 cells in shake flasks within a sophisticated multi-cabinet incubator. Learn how multi-cabinet incubators with adjustable parameters can optimize cell culture conditions and explore the methods used to achieve optimal conditions for viral production. |
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UPSTREAM MANUFACTURING SOLUTIONS |
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| Webinar: Bringing It All Together – Data Harmony in the Bioprocess Ecosystem | Join us on September 20th to learn how to achieve seamless data integration within your bioreactor system by unifying information from various sources to gain a holistic view of your cultivation process. Discover how to contextualize bioreactor data using cutting-edge tools to create valuable insights about your cultivation and embrace automation methodologies to free up resources for critical decision-making. |
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| Webinar: Formula Considerations for the Development of High Concentration Biopharmaceuticals | In the pursuit of attaining higher-concentration drug products several obstacles arise. These challenges include increased aggregation, formation of subvisible particles, and viscosity as well as process development challenges, such as Donnan Effects. This webinar will explore the fundamental formulation principles, strategies, and tools for producing successful high-concentration formulations including small scale tangential flow filtration to understand pH shifts. Click here to learn more |
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