Paveway™ PLUS Microbial Expression System For The Efficient Production Of Therapeutic Proteins

The efficient expression of therapeutic proteins in microbial or mammalian systems is one of the major bottlenecks in the production of biopharmaceuticals.

Paveway™ is an innovative expression system in Escherichia coli (E. coli) that enables the creation of novel recombinant strains where the lead strain selection is based on titer possible within 6 weeks of program initiation. Since its launch in 2007, Paveway has become a well proven E. coli expression system, producing >140 different therapeutic proteins successfully expressed with a variety of accumulation routes including intracellular soluble, intracellular insoluble and periplasmic secretion.

In this article, review how the system works and a success story of the system in action.