A Single-Use, Scale-Down, Predictive Solution For Intensified Perfusion Development

Perfusion is becoming a typical approach to achieving upstream process intensification. The ability to scale down these processes, however, has been limited due to lack of appropriate technologies. Labs cannot run enough bench scale 2L bioreactors with cell retention devices due to resource constraints and high throughput systems lacking the required perfusion or control capabilities.

Here, we describe a new microbioreactor system that fulfills this throughput-performance gap, providing single-use, perfusion bioreactors with 2mL working volume that can replicate bench scale perfusion processes at industrially relevant cell densities.