Newsletter | September 29, 2025

09.29.25 -- How To Grow CHO Cells Without Cysteine, Tyrosine Feeds

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Webinar: Cell Bank & Scale Up Strategies for MSC & Exosome Manufacturing

This webinar explores two key decisions affecting the manufacturability and long-term success of advanced therapies. RoosterBio experts will share strategies for reducing costs, risks, and timelines in GMP manufacturing through optimized cell banking. Attendees will learn about major risk areas, effective banking strategies, and scale-up techniques for MSC and exosome production to support clinical and commercial success. Register here.

FOCUS ON UPSTREAM MANUFACTURING

How To Grow CHO Cells Without Cysteine, Tyrosine Feeds

Researchers at Pfizer are developing a cell line that synthesizes these amino acids autonomously, which could reduce costs and increase stability.

Rethinking Glycosylation: A Primer On Enzymatic Control

Learn how to gain precise control over one of the most common and critical forms of protein modification for therapeutic benefit and stability.

Cell-Based Screening: Accelerating Therapeutic Development

Discover how advanced transfection technology can accelerate therapeutic development. Explore faster, more flexible cell-based screening assays, including mammalian display, to optimize your research.

The Power Of The Pool: Using Bulk Cultures For Clinical Trial Manufacturing

Stable bulk cultures, made highly uniform using transposase-mediated technologies, may be the key to expediting clone selection for many biopharmaceutical applications.

Why Cell Washing Is The Hidden Bottleneck In Gene-Edited Cell Therapy

Scaling up life-saving gene-edited cell therapies means tackling production inefficiencies. Overcoming the time-consuming and risky cell washing step is crucial for clinical and commercial success.

Tackling Encapsidated Host Cell DNA To Improve Quality

Discover a cell line that enhances rAAV production by reducing host cell DNA encapsidation, improving safety and efficiency through genetic modifications that inhibit apoptotic DNA fragmentation.

Data-Driven CHO Bioprocess Optimization And Scale-Up

Learn how at-line cell culture media analysis enhances mAb production by refining nutrient feed strategies, reducing toxic metabolites, and improving yields while lowering costs.

Disruptive Technologies Transforming Upstream Process Intensification

The demand for complex biologics is driving the need for intensified cell culture technologies. Perfusion using ATF has emerged as a leading solution to increase cell density and productivity.

Single-Use Multi-Layer Film's Cell Growth Performance Compared To Glass

Explore the findings of studies analyzing the performance of upstream bioprocessing with Ultimus® film, a single-use, multi-layer film with a fluid contact layer free of Irgafos® 168.

Choosing The Most Effective Transfection Reagent For Your Needs

Choosing the right transfection reagent can be confusing. This guide explores product names, their applications, and the importance of testing beyond labeled uses.

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Webinar: Quality Without Compromise: Supply Resiliency for Bioprocessing Amid Global Volatility

Bioprocessing success depends on supply chain strength and uncompromising quality. Join Thermo Fisher Scientific’s experts to discover proactive strategies that protect against disruption, ensure CGMP compliance, and accelerate biologics to market. Learn how resilient sourcing, quality-driven distribution, and innovative raw material programs can save cost, time, and resources—empowering you to stay competitive in an evolving market. Click here to learn more.

UPSTREAM MANUFACTURING SOLUTIONS

Quantum Flex Cell Expansion System - Terumo BCT

Scale-Up In Single-Use Bioreactors: From R&D To Manufacturing - Eppendorf SE

Lowest Profile 2-Axis Nanopositioner: Nano-Bio Series - Mad City Labs, Inc.

Compact Microbiological Cooled Incubator - PHC Corporation of North America

Closed System Solutions - Corning Life Sciences

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