Newsletter | August 11, 2025

08.11.25 -- How Lumen Is Putting The "Farm" In Biopharma

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Webinar: Unlock Viral Vector Yield and Efficiency with Upstream Intensification

Discover how Repligen's TFDF technology is changing viral vector manufacturing. In this webinar, you’ll learn how high-density, perfusion-based production using HEK293 cells and ready-to-use plasmids can boost AAV and LVV yields by up to 30 times—while keeping quality high. See how this efficient, scalable process helps lower costs and speed up access to life-changing gene therapies and vaccines. Click here to learn more.

FOCUS ON UPSTREAM MANUFACTURING

How Lumen Is Putting The "Farm" In Biopharma

Lumen Bioscience's SVP of production and development, Craig Behnke, Ph.D., explains how the company is cutting costs and rethinking upstream manufacturing with its algae-based production platform.

In Vitro Glycoengineering – Suitability For BioPharma Manufacturing

In this assessment of the in vitro glycoengineering technology we determine if it is suitable for the development, manufacturing, and analysis of therapeutic proteins.

5 Best Practices To Keep Your Incubator Shaker Contamination-Free

Learn five essential best practices to maintain a sterile incubator shaker environment, from routine cleaning and humidity control to advanced HEPA filtration for reliable results.

Practical Tips For Maintaining Healthy Cell Cultures

Humidity is a critical yet often overlooked factor in cell culture. Learn how it impacts cell viability and discover practical strategies to maintain optimal conditions for reliable results.

Scalable iPSC Differentiation To NK Cells With Cytotoxic Potential

Learn about an innovative serum-free method to differentiate induced pluripotent stem cells (iPSCs) into natural killer (NK) cells, offering scalable solutions for immunotherapy with enhanced cytotoxic potential.

The 3 Most Overlooked Costs In Monoclonal Antibody Production

Explore the dynamic field of therapeutic biotechnology, examining the intricacies of mAb manufacturing and uncovering the often-overlooked factors driving high production costs.

Overcoming Commercialization Challenges Of Lentiviral-Based Therapies

Review the results obtained for our proprietary HEK293T 2G7 suspension cell line for LVV production by transient transfection in serum-free, chemically-defined and animal component-free media.

Why Cell Washing Is The Hidden Bottleneck In Gene-Edited Cell Therapy

Scaling up life-saving gene-edited cell therapies means tackling production inefficiencies. Overcoming the time-consuming and risky cell washing step is crucial for clinical and commercial success.

Double, Double, Experts Huddle, Cells And Bioprocess Bubble

Biomanufacturing leaders unite to optimize exosome/EV production. Explore their combined upstream/downstream approach for optimized cell culture, purification, and quality control.

Innovations In Perfusion Bioprocessing

Gain valuable insight into the optimization and scalability of perfusion media and processes, driving progress in biotechnological processes for monoclonal antibody production.

Making MSCs GMP: A Compliant Workflow

Generate GMP-compliant mesenchymal stem cells (MSCs) at scale with a closed, automated workflow. Learn how to optimize MSC harvest yields and ensure trilineage differentiation.

Streamline The Path To FIH Trials With Advanced Cell Line Development

Many CDMOs cannot handle complex recombinant proteins, which often require a CLD process fully integrated with other CDMO components, including analytics and formulation development.

UPSTREAM MANUFACTURING SOLUTIONS

Minimizes Shear Forces On Cells: UniFuge UFPilot - CARR Biosystems

Large Scale Cell Culture Facility - Boehringer Ingelheim Biopharmaceuticals GmbH

Cell Line Development Solutions - ATUM

A Scaled-Down Solution For Simple, Robust Upstream Intensification - Repligen

An Off-The-Shelf Transient Cell Line For Viral Vector Production - Cytiva

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