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| Webinar: Seals & Stability: Preventing Failures in Synthesis and Chromatography Columns | This webinar highlights the overlooked importance of seals and O-rings in oligonucleotide synthesis and chromatography. Chuck Haeger shares real-world cases showing how proper maintenance and skilled teams prevent failures. Attendees will learn strategies to boost column longevity, reduce risks, and ensure high-quality output—ultimately supporting the production of life-changing medicines. Click here to learn more. |
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FOCUS ON DOWNSTREAM MANUFACTURING |
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By Jai A. Pathak, Ph.D., AstraZeneca | Complex problems can have simple solutions. That's what a team at AstraZeneca found when they set out to reduce false rejection rates in vials containing mAbs. | |
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Challenges And Considerations For Purifying Multispecific Molecules | By Bioprocess Online Live | The structural complexity and variability of multispecific molecules presented purification challenges, from incorrect chain pairings to increased aggregation, fragmentation, and lower yield compared to standard mAbs. Developers shared how they overcame these challenges to achieve high purity and discussed key considerations for downstream developers when designing these processes. Bioprocess Online editor Tyler Menichiello explored these questions with Jian Ren, Ph.D., a principal scientist in downstream process development at AbbVie, and Mark Fitchmun, founder, president, and CEO of Somatek. |
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| Increasing Downstream Manufacturing Process Efficiencies | Article | By Tristan Passeggiati, Asahi Kasei Bioprocess | Downstream processing can account for up to 80% of biopharmaceutical production costs. Optimizing this stage is crucial for resource management, product quality, and overall yield. |
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| Stopper Migration In Frozen Pre-Filled Syringes | White Paper | By Jayasree M. Srinivasan, Ph.D., Simtra BioPharma Solutions | Review a semi-automated method for dynamically assessing plunger migration under controlled variations in temperature and pressure, utilizing computer vision tools. |
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DOWNSTREAM MANUFACTURING SOLUTIONS |
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