Newsletter | April 14, 2025

04.14.25 -- From BPI West: An Upstream Scientist's Advice On Target Glycosylation

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Webinar: From Cell Line Development to Upstream Optimization: Enhancing Biologics Quality and Productivity

Join Samsung as they share how to enhance purity, stability, overall performance and further increase productivity by 2-fold while maintaining quality. In addition, learn how the S-AfuCHO™ cell line, developed from its proprietary S-CHOice® host cell, produces fucose-free antibodies with significantly enhanced ADCC activity, leading to more potent therapeutic effects. Click here to learn more.

FOCUS ON UPSTREAM MANUFACTURING

From BPI West: An Upstream Scientist's Advice On Target Glycosylation

Bioprocess Online spoke to an upstream scientist at Bristol Myers Squibb during this year's BPI West. Here's what he had to say.

How Tunable Cell Processing Solutions Ensure Separation Efficiency

Single-use tubular bowl centrifuges are standing out to cell therapy developers for their ability enable the optimal balance between high separation efficiency, high productivity, and low shear.

Advancements In Aseptic Connection Technologies

Expand your knowledge on the latest innovation in the sterile connector space including the new 1.5” flow path connector, disconnection solution, and more.

Study Of Small Bioreactor Expansion Kinetics During Expansion Protocol

Mesenchymal stem cells have been used to show equivalent expansion kinetics during a 7-day expansion protocol on both the small and standard bioreactors revealing efficiency differences.

Serum Replacement Performance On T Cells

A serum replacement for promoting T cell growth and functionality in cell therapy development shows comparable or superior performance to traditional human serum supplements. Learn more in this deep dive.

Exploring Perfusion Technology For Manufacturing Process Intensification

Perfusion cell culture technology supports high cell densities and product yields for viral vaccine manufacturing, offering a reliable way to produce high-quality cells at a commercial scale.

High-Yield Expression Of Complex Proteins From Stable Pools

This study presents the development of apoptosis-resistant CHO cell lines (DKO1 and DKO2), using electroporation technology, with the goal of enhancing biotherapeutic production.

Uncover The Intricacies Of Transposase-Mediated Genome Engineering

In this presentation, experts provide insight into transposase-mediated genome engineering, genetic quality control, and the maintenance of genetic stability in cell line generation.

Tackling Encapsidated Host Cell DNA To Improve Quality

Discover a cell line that enhances rAAV production by reducing host cell DNA encapsidation, improving safety and efficiency through genetic modifications that inhibit apoptotic DNA fragmentation.

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The debate rages on. While the automation that enables continuous processing gets a lot of hype, there are plenty of dyed-in-the-wool biopharma pros who contend that process optimization and intensification yield comparable benefits, without requiring the capital-intensive process overhaul that continuous demands. Join Bioprocess Online Live for a virtual deep dive into the scalability, sustainability, and capital implications of the continuous-versus-optimized debate. Registration is free thanks to the support of Cytiva.

UPSTREAM MANUFACTURING SOLUTIONS

Integrated Biotech Services: From Strain To Commercial Product - Lonza

Vertical-Wheel Bioreactor Product Guide - PBS Biotech, Inc.

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Webinar: Sustainable Manufacturing Through Efficient BioProduction Unit Operations

Join our webinar to explore sustainable bioprocessing solutions, tackling plastic waste with biobased consumables, process intensification, and optimized operations. Learn how seed train intensification, high-density cell banking, and efficient bioreactor scaling can reduce the environmental footprint. Gain insights from experts on implementing greener, more efficient workflows in biomanufacturing for a sustainable future. Click here to learn more.

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