Newsletter | October 7, 2026

10.07.26 -- Engineering Better ADCs, Part 1: MoA, Conjugation Chemistry, And More

SPONSOR

Evaluation of a New Multimodal Resin for Emerging Biotherapeutics

As biotherapeutics become more complex, purification scientists need flexibility for process optimization. This 15-minute on-demand webcast, Merck & Co., Inc., presents how Bio-Rad’s Nuvia™ wPrime 2A Media, a weak anion exchange and hydrophobic interaction chromatography (AEX-HIC) mixed-mode resin, provides a broad design space and improved yields while reducing aggregates and HCPs in comparison to existing monoclonal and bispecific antibody workflows. Watch now and request a sample.

FOCUS ON DOWNSTREAM MANUFACTURING

How To Define, Monitor, And Hit Critical Endpoints

Improve UF/DF repeatability by defining clear concentration and diafiltration endpoints, matching them with appropriate measurements, and applying real-time in-line analytics to reduce variability.

Process Intensification Of Protein A For mAb Purification

See how membrane and multi-column chromatography compare with traditional Protein A capture in productivity, cost, scalability, and performance, including results from pilot-scale membrane testing.

Best Practices For When To Leverage Mass Spectrometry For HCP Analytics

Go beyond the ELISA by leveraging mass spectrometry. Identify specific high-risk proteins and ensure your purification process meets the highest standards of safety.

Preventing Fouling And Restoring Performance With Targeted Cleaning

Protein A chromatography intensification can increase productivity, but it may also affect process robustness. Explore key tradeoffs, operational challenges, and practical considerations.

End-To-End Solutions To Bridge Every Gap In Your Peptide Characterizations

Discover end-to-end strategies for therapeutic peptide characterization, including purity, structure, stability, and more, alongside expert services designed to strengthen workflow consistency.

Simplifying Downstream Processing For Complex Biologics

Uncover how integrated approaches and process simplification can reduce bottlenecks, improve consistency, and support high-quality manufacturing outcomes across increasingly challenging pipelines.

DOWNSTREAM MANUFACTURING SOLUTIONS

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MPLC System: Efficient Purification For Mid-Sized Therapeutics - Asahi Kasei Bioprocess

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Resin Guide: A Trusted Resource For Biotherapeutic Purification - Bio-Rad Laboratories, Inc.

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High Binding Capacity And Short Residence Time For Antibody Purification - W.L. Gore & Associates

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Protein A Resin With High Binding Capacity - Cytiva

SPONSOR

Webinar: Advancing drug product manufacturing with a risk-based approach to single-use system integrity

Single-use systems are widely used in biopharmaceutical manufacturing, but expectations for system integrity continue to evolve. This session explores key control points across the SUS lifecycle and how a holistic approach can strengthen contamination control strategies. Learn how clear requirements, regulatory awareness, and effective integrity strategies can support compliance, operational efficiency, and product quality. Click here to learn more.

FOCUS ON FILL-FINISH

Engineering Better ADCs, Part 1: MoA, Conjugation Chemistry, And More

The field has evolved considerably in antibody–drug conjugate (ADC) science. In this first article of a two-part series, let's discuss how to engineer better ADCs, covering MoA, conjugation chemistry, and more.

Neoantigen-Based Personalized Cancer Vaccine

Personalized cancer vaccines are advancing quickly, but effective delivery remains a major hurdle. Learn how mRNA and lipid nanoparticle design influence targeting, endosomal escape, and repeat dosing.

Why Pharmaceutical Scientists Trust The Discovery Core Rheometer

Drug formulations demand more than single‑point viscosity data. Gain insight into how rheology reveals stability, flow, and structural behavior across suspensions, topicals, and injectables.

Automated Fill And Finish For Cell Therapy

Automated fill-finish systems protect sensitive cell therapies using low-shear handling to maintain dose uniformity, cell viability, and process consistency across every batch.

5 Key Questions On Implementing Pharma 4.0 Solutions For Fill-Finish

Pharma 4.0™ leverages IoT, AI, and automation to enhance drug quality. Evaluate your fill-finish line readiness by considering five key questions on modularity and high-risk process automation.

FILL-FINISH SOLUTIONS

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Future‑Ready Stickpack Line For Pharmaceutical Packaging - Koerber Pharma

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Capabilities Update July 2026: Fill/Finish - Ardena

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