03.12.25 -- Automating Digital Twins Implementation In Downstream Bioprocessing

Determining size homogeneity of a mAb in solution is key for comparability and characterization. For this study, an IgG1 antibody was cleaved into antigen-binding fragments, followed by Protein A purification.

Evaluate TFF formats (hollow fiber and flat sheet) and membrane chemistries for AAv gene therapy processing, assessing performance, scalability, economy, and closed processing options.

Is it difficult to reproduce laboratory purification results at process scale? We evaluated three prepacked columns from 1.6 to 33 cm column inner diameter (ID) to observe their purification profiles.

Delve into the specific challenges encountered in the development of high-concentration formulations and gain an overview of current state-of-the-art solutions for subcutaneous administration.

Explore the capabilities of two new chromatography systems that meet key requirements for rapid cycling chromatography (RCC) and enhance performance for membrane-based ion exchange.

This study demonstrates that Retrovirus-like particles (RVLPs) can be used to accurately assess viral clearance, providing a valuable tool for the development of biopharmaceutical manufacturing processes.

Discover how our efficient strategies can propel your mAb from discovery to clinical manufacturing in as little as 18 months.

Explore high voltage leak detection, headspace analysis, and vacuum and pressure decay as applied in pharmaceutical manufacturing.

Explore the benefits of prefilled syringes to enhance product convenience, reduce drug waste, and streamline your pharmaceutical manufacturing process.