Poster

A Unique Rapid Approach For Media And Feed Optimization

Source: Sartorius
Sartorius-Logo-350 wide

CHOptimizer® includes media application specialist guidance along with a portable ambr® 15 workstation that is brought onsite to optimize a CHO fed-batch process. After using CHOptimizer®, a 17 day fed-batch process was developed. From simple fed-batch (glucose only) to fed-batch, in less than 6 months an IgG1 producing cell line peak VCD was improved 2.5-fold from 4.5 × 106 cells/mL to 11 × 106 cells/mL and titer was improved 4-fold from 0.5 g/L to 1.9 g/L.

Biopharmaceutical companies today are challenged to develop high producing cell lines as quickly as possible. Commercially available media may fall short of performance expectations in order to meet targets. Alternatively, fully customized media and feed development requires significant funding, time, and in house expertise in media development. To address these challenges CHOptimizer ® offers dedicated media application specialists support, who guide customers through a series of experiments designed to optimize a fed-batch process using prequalified blends of well-characterized, Chemically Defined (CD), and Animal Origin Free (AOF) media. CHOptimizer® combines the performance of Lonza cell culture media with the power of the ambr® 15 workstation which facilitate high throughput Design of Experiments (DoE) analysis.

access the Poster!

Get unlimited access to:

Trend and Thought Leadership Articles
Case Studies & White Papers
Extensive Product Database
Members-Only Premium Content
Welcome Back! Please Log In to Continue. X

Enter your credentials below to log in. Not yet a member of Bioprocess Online? Subscribe today.

Subscribe to Bioprocess Online X

Please enter your email address and create a password to access the full content, Or log in to your account to continue.

or

Subscribe to Bioprocess Online