Upstream Manufacturing Webinars

  1. Advanced Adherent Corning Platforms For Scalable Viral Vaccine Manufacturing 7/5/2026

    Optimize vaccine production by balancing adherent cell line kinetics with advanced scaling methodologies. Learn to navigate cellular metabolism bottlenecks and implement perfusion strategies.

  2. Upstream Decisions Influence Downstream Challenges 7/1/2026

    In this segment from the Bioprocess Online Live event, “The Levers And Tradeoffs That Drive Process Productivity,” panelists David Scherr, Ph.D. (AstraZeneca) and Vadim Klyushnichenko, Ph.D. (Calibr-Skaggs), answer the question, “What should developers be thinking about upstream to avoid downstream complications?” Klyushnichenko believes process-wide considerations like this begin earlier than cell line development at the product’s molecular construct itself.

  3. Productivity Gains Upstream Apply Pressure Downstream 7/1/2026

    In this segment from the Bioprocess Online Live event, “The Levers And Tradeoffs That Drive Process Productivity,” panelists David Scherr, Ph.D. (AstraZeneca) and Vadim Klyushnichenko, Ph.D. (Calibr-Skaggs), reflect on the progress that’s been made in terms of productivity gains and the “ceiling” that mAbs face, and how these upstream gains stress downstream operations. They also discuss how molecular complexity relates to challenges in purification.

  4. Continuous Manufacturing As A Powerful Productivity Lever 7/1/2026

    In this segment from the Bioprocess Online Live event, “The Levers And Tradeoffs That Drive Process Productivity,” panelists David Scherr, Ph.D. (AstraZeneca) and Vadim Klyushnichenko, Ph.D. (Calibr-Skaggs), discuss the potential of perfusion and continuous manufacturing to improve productivity through smaller facility footprints and greater output over time. They also examine the challenges associated with these approaches, including cell-line stability, process monitoring, and the cost of operational mistakes.

  5. Next-Generation Molecules Challenge Notions Of Yield And Performance 7/1/2026

    In this segment from the Bioprocess Online Live event, “The Levers And Tradeoffs That Drive Process Productivity,” panelists David Scherr, Ph.D. (AstraZeneca) and Vadim Klyushnichenko, Ph.D. (Calibr-Skaggs), discuss how the process-related associated with next-generation molecules like bispecifics and trispecifics complicate downstream purification efforts impurities (e.g., chain mispairings). They agree that mitigating these impurities is a developmental challenge both upstream and downstream.

  6. Understanding Fixed Variables And Working Within Their Constraints 7/1/2026

    Some things are intrinsic, unchanging realities of a process — molecular complexity, product developability, and facility fit, to name a few. In this segment from the Bioprocess Online Live event, “The Levers And Tradeoffs That Drive Process Productivity,” panelists David Scherr, Ph.D. (AstraZeneca) and Vadim Klyushnichenko, Ph.D. (Calibr-Skaggs), discuss these “non-pullable levers” of process development and advise teams on how to work within their boundaries.

  7. Breaking the Titer Ceiling: Smarter Media Design for Higher Productivity 6/30/2026

    A bottom-up, data-driven media design approach shows how targeted nutrient optimization overcomes metabolic limits to boost culture performance and titer while maintaining product quality and process consistency.

  8. Catalent Capabilities Update June 2026: Cell Line Development 6/24/2026

    Discover how an integrated approach to transient expression, cell line development, and manufacturing can accelerate biologics development from gene to IND.

  9. How Intensified Upstream Processing Improves Scale-Up And Tech Transfer 6/22/2026

    Intensified upstream processing can improve scalability and maintain quality. Learn how automation, PAT, and data-driven control strategies help modernize workflows and support consistent performance.

  10. Generate Stable High-Producing Clones In 14 Weeks 6/18/2026

    Rising complexity is putting pressure on cell line development. Discover a streamlined approach that enables rapid generation of stable clones with strong titers and long-term consistency.