Upstream Cell Line Development

1. Navigating The Workflow From Process Development To GMP Manufacturing For Making Clonal iPSC-Derived Master Cell Banks 3/7/2022

   In this video, we present data for optimizing choices of which combinations of GMP-compatible matrix, dissociation reagents, and media can best be employed for single cell cloning of iPSCs in process development.

2. Is Evaporation Important For Optical Biosensors? 2/17/2022

   If your sample is open to evaporation effects causing your concentration to change, will your data, and potentially your conclusions, be unreliable?

3. Break Down Roadblocks To Clinical Success - Cell Line Development 12/27/2018

   Watch this video to learn the important decisions that each biopharma executive must make to break down roadblocks during the critical first step of cell line development and bring their molecule to clinic successfully.

4. Can Kinetics Provide Detailed Information About Binding Interactions? 2/17/2022

   See the potential value kinetics brings to deepen the understanding of biological processes.

5. Understanding The Oligonucleotide Synthesis Process 1/24/2023

   Synthetic oligonucleotides are primarily used in therapeutics, as well as in diagnostic kits and PCR primers. This animation explains the repetitive four-step cycle of the oligonucleotide synthesis process.

6. Increase The Titer Of A Difficult To Express Molecule 12/11/2019

   What happens if you have a promising molecule but can’t engineer a cell line to deliver the titer needed to support clinical development?  A low process titer may render the molecule, such as an antibody, too costly to manufacture and unsuitable for continued investment. Learn how our client achieved a nearly 4-fold titer increase.

7. Overcoming Cloning Inefficiencies To Accelerate New Protein Therapeutics 10/24/2023

   Watch as a scientist from Advanced Instruments demonstrates how the InstiGRO™ CHO cell culture supplement can be used to enhance clonal outgrowth during single cell seeding experiments.

8. Can You Run Crude Samples Using An SPR Instrument? 2/17/2022

   We explore a common misconception and provide examples of complex material being used in an SPR system.

9. VIPS™ For Cell Therapy: Updates 9/30/2022

   Watch to learn about the latest developments to VIPS™ which address the needs of cell therapy companies moving towards GMP manufacturing.

10. Accelerate Identification Of High-Producing Cell Lines 12/11/2019

    When companies are putting in place an upstream process, a critical step is generation of a cell line expressing the protein of interest. Unfortunately, the search for the best-producing clone is often compared with looking for a needle in a haystack. Watch our video to learn about our mini-pool approach and the value of automated systems to efficiently create, screen and isolate high producing clones with reduced costs.