Thermo Fisher Bioproduction Insights

  1. Lentiviral Vector Characterization For Cell And Gene Therapy Manufacturing 6/20/2024

    This study focuses on characterizing recombinant LVVs used in gene-modified cell therapies, utilizing two real-time PCR assays adapted to the QuantStudio™ Absolute Q™ Digital PCR System.

  2. Residual DNA Testing: Homebrew vs Off-The-Shelf Solutions 6/19/2024

    Compare the steps to setting up your own residual DNA testing solution to the steps for setting up a commercial residual DNA testing solution.

  3. High-Performance Extraction And Quantitation Of Host-Cell Residual DNA 6/19/2024

    This study presents a high-efficiency method for extracting and quantifying residual DNA from host cells using a semi-automated, high-throughput workflow.

  4. Maximizing Scale-Up Efficiency Of A mAb Upstream Process 6/17/2024

    This study demonstrated the effectiveness of a medium and feed system when tested at three different scales for its ability to high-quality, fed-batch monoclonal antibodies.

  5. Mycoplasma Testing In Monoclonal Antibody Production 6/17/2024

    Prevent costly disruptions in your bioproduction process. Discover how a PCR-based method can quickly detect the presence of mycoplasmas in raw materials, cell banks, and in-process and lot-release samples.

  6. Simultaneous Extraction Of Mycoplasma, MMV, And Vesivirus Nucleic Acids From A Single Sample 6/7/2024

    Achieve early detection of cell culture contamination with a nucleic acid extraction system to provide an integrated system for rapid and sensitive detection of mycoplasma, MMV, and vesivirus.

  7. Meeting Regulatory Requirements With Confidence 6/7/2024

    An outbreak of mycoplasma can halt a biopharmaceutical facility's production for months. Explore the impact of mycoplasma contamination and the most accurate and sensitive way to detect it.

  8. Residual Plasmid Quantification In Gene Therapy Manufacturing Workflows 6/7/2024

    This article details the design and application of a Plasmid DNA - Kanamycin Resistance Gene (pDNA-KanR) kit for residual plasmid quantification in gene therapy manufacturing.

  9. Optimize T Cell Phenotype With One-Step Isolation And Activation 5/10/2024

    This comparative bench-scale study features active-release beads that could improve the reliability, consistency, and longevity of cell therapy treatments.

  10. Overcoming Rapid Growth Challenges With Process Liquid Preparation 5/10/2024

    With a helpful assessment and the right process liquid preparation services, the CDMO featured in this study was able to find a path toward meeting the surge in demand for a client's therapeutic .