milliporesigma videos

  1. Welcome To The World Of Innovation 5/19/2020

    Curiosity, science and innovation are at the heart of everything we do. We are pioneers shaping the future of manufacturing. Every day we are pushing boundaries, collaboratively working on disruptive, digitally-enhanced and model driven bioprocessing technologies through an innovative platform converging digital and advanced processing tools. We empower biomanufacturers to confidently enter the era of bioprocessing 4.0. This holistic solution will accelerate the transformation to the data-driven revolution.

  2. Strategies To Reduce Regulatory Risks In Gene Therapy 5/15/2020

    Learn how to mitigate regulatory risk for your gene therapy process.

  3. Single-pass Tangential Flow Filtration For Bioprocessing 4/2/2020

    Experiencing bottlenecks in your downstream process? Pellicon® Single-Pass TFF increases your productivity, capacity while reducing costs!

  4. Concentrate Your Product After One Path With Pellicon® Single Pass Tangential Flow Filtration 4/2/2020

    Discover Pellicon® Single-Pass Tangential Flow Filtration, the versatile ultrafiltration technology for process intensification.

  5. Making Data Work 12/16/2019

    What is big data? What is Bioprocess 4.0? How do you leverage data to make better informed decisions? This video explores the role data plays in biopharma scale-up and manufacturing. Learn how to make data work for you.

  6. Reduce The Level Of Host Cell Protein In The Bioreactor Harvest 12/11/2019

    Host cell proteins (HCPs) are an inevitable byproduct of biologics manufacturing and can have an impact on product quality and efficacy as well as patient safety. Processes designed to remove HCPs from the bioreactor harvest must not only be successful in achieving acceptable limits, but also be scalable. Learn how we helped our client reduce the level of HCPs in the bioreactor harvest prior to a production run to supply drug substance for a scheduled Phase 1 clinical trial in a very tight timeline.

  7. Optimize The Formulation Of A Monoclonal Antibody 12/11/2019

    You have a molecule of interest and need an effective formulation to maximize stability and minimize aggregation. As with all formulations, it is essential that the buffers and excipients ensure stability of the drug substance, be compatible with each other and meet regulatory requirements. An emerging biotech company sought our help in developing a formulation for a monoclonal antibody. Learn how we have delivered an optimized formulation for this customer in three months.

  8. Scale Your Process Directly From 3L To 2,000L Blindfolded 12/11/2019

    In the biotech industry, you need to move quickly and use resources efficiently to advance a drug candidate into the clinic and ultimately onto the market. Being able to quickly produce a batch at the right time and at the right size is essential to support development and get to the finish line faster. We developed a strategy to enable a direct, efficient and robust tech transfer of a monoclonal antibody production process from a 3L bioreactor to 2000L without the need for any intermediate volumes.

  9. Increase The Titer Of A Difficult To Express Molecule 12/11/2019

    What happens if you have a promising molecule but can’t engineer a cell line to deliver the titer needed to support clinical development?  A low process titer may render the molecule, such as an antibody, too costly to manufacture and unsuitable for continued investment. Learn how our client achieved a nearly 4-fold titer increase.

  10. How To Generate A High-Producing Cell Line In Fast-Track Mode 12/11/2019

    Cell line development processes can be quite time consuming and labor intensive. When our clients have a very challenging timeline, we can begin process development in parallel with cell line development, further accelerating timelines. What are the risks and how do you minimize risk?