MilliporeSigma Brochures

  1. High Temperature Short Time (HTST) Treated Glucose 8/17/2020

    HTST pasteurization is a highly effective method to inactivate viruses. It involves the rapid heating of the material to a predetermined temperature (>100 °C) and holding it at that temperature for a specified time to inactivate adventitious viral agents that may be present. This technology has been typically used as an in-house treatment for high risk bioreactor feeds, such as glucose, and is becoming an integral part of many biopharmaceutical companies’ viral risk-mitigation strategies.

  2. Cellicon™ Perfusion Filter and Controller Data Sheet 8/7/2020

    The benchtop Cellicon™ Perfusion Solution is designed to meet your perfused seed train challenges. It consists of a controller and a flat sheet cell retention filter with a single-use assembly running in tangential flow filtration mode. This easy‑to‑use solution increases perfusion process efficiency, and provides real-time monitoring and control for reliable and consistent performance.

  3. EX-CELL® Advanced HD Perfusion Media 7/15/2020

    EX-CELL® Advanced HD Perfusion Medium is a chemically defined cell culture medium designed specifically for intensified perfusion processes with Chinese Hamster Ovary (CHO) cells. This medium was developed to reach and maintain high cell densities at low cell specific perfusion rates (CSPR), while supporting high volumetric productivities of monoclonal antibodies and recombinant proteins in suspension culture.

  4. Eshmuno® CMX Chromatography Resin Data Sheet 6/18/2020

    Eshmuno® CMX chromatography resin is a highly selective mixed mode chromatography resin for difficult to purify mAbs, ADCs and fusion proteins. This innovative resin combines weak cation exchange properties with hydrophobic interaction, providing high selectivity for mAb, fusion protein and ADC purification as well as separation of low molecular weight impurities and Host Cell Proteins (HCPs).

  5. Flexible Manufacturing Of Vaccines 4/6/2020

    Flexible manufacturing accelerates vaccine development and production to ensure that vaccines are available where and when they are needed most. We can guide you through each step of your complex journey to establish a single-use facility.

  6. BioReliance® Gene Therapy Services 3/17/2020

    We are your partner for manufacturing and testing of viral gene therapies and gene-modified cell therapies. We offer manufacturing and biosafety testing for every stage of gene therapy development.

  7. Benzonase® endonuclease Safety Plus Emprove® Expert Data Sheet 1/15/2020

    Benzonase® endonuclease — the smart solution for DNA removal in biopharmaceutical production.

  8. Benzonase® endonuclease Safety Plus Emprove® Expert Brochure 1/15/2020

    With its new features, Benzonase ® endonuclease Safety Plus Emprove® Expert is ideally suited for manufacturing of cell and gene therapy agents such as adeno associated and lenti viruses, oncolytic viruses, and viral vector vaccines.

  9. Integrated Vector Production Capabilities 10/29/2019

    From products and services to complete manufacturing offerings, find out how MilliporeSigma can help you produce better, faster viral vectors.   

  10. Product Characterization Assay Package - Interlot And Biosimilar Comparability 7/14/2019

    Monoclonal antibodies (mAbs) are highly complex biomolecules easily affected by changes in the biopharmaceutical manufacturing process. Something as simple as a temperature fluctuation can produce a change in higher order structure (HOS) that renders the mAb less active or inactive. Whether your mAb is an original product or a biosimilar, our comparability studies are designed to ensure robust and reproducible mAb production.