On-Demand Cell Line Development Webinars

  1. Osmolality: Critical Quality Attribute For Cell Line Development, Cell Therapy 11/19/2021

    A discussion on the use of osmolality in bio-production and in earlier process development, and the case for more frequent, earlier monitoring in cell line development and cell therapy.

  2. The Importance Of Cell Media Analysis In Upstream Bioprocess Development 10/13/2021

    Experts from industry and academia to explore current trends in upstream bioprocessing and the impact of real-time cell media analysis on process improvements and process analytical technologies.

  3. Production Of Therapeutic Proteins In CHO Cells 10/12/2021

    The need to optimize cell culture conditions for every cell line in a product-specific manner can lead to extended timelines and substantial cost in cell line development.

  4. Cell Line Development Toolbox For Intensified Bioprocessing 9/8/2021

    If intensified processes lead to productivity improvements, then the Cell Line Development Toolbox holds the answers to make intensified bioprocessing a reality. Learn more about these technologies to optimize clone selection, shorten seed trains, and speed up early process development.

  5. Rapid Cell Culture Media Analysis For C> Process Development 6/3/2021

    Experts discuss how to accelerate process analytics with fast nutrient screening at critical time points and the benefits of rapid media analysis in cell therapy development and viral vector production.

  6. Tips For Purifying Cryo-EM Samples 5/20/2021

    Cryo electron microscopy can help you determine structures for challenging proteins like membrane proteins and larger complexes. This presentation offers tips on purifying your cryo-EM samples.

  7. Accelerating Biologics Drug Development With An Analytical Toolkit 5/20/2021

    Using key attributes to monitor development processes can decrease timelines, improve product quality, reduce cost, and enable implementation of key knowledge gained from an analytical toolkit.

  8. Maximizing Product Titre By Strategic Control Of Osmolality In Mammalian Cell Bioprocesses 4/30/2021

    Osmolality is a key process parameter in mammalian cell bioprocesses that affects both specific cell growth and specific cell productivity. Published data shows that hyperosmolality, used in a targeted way at particular stages of the biological production process, for certain cell types, can enhance final product yield significantly. This presentation reviews the strategies that can be used to manipulate osmolality to increase production yields of monoclonal antibodies and other recombinant proteins.

  9. Osmolality: A Predictor In Mammalian Cell Culture 4/30/2021

    In this presentation we explored the quality and significance of osmolality as a predictor for titer, glucose consumption, and growth-inhibitory by-products such as ammonium in mammalian cell culture. The measurements of different runs were used to establish correlations with osmolality and independent runs to test the predictive power of osmolality. Interestingly the osmolality is a good predictor for glucose, ammonium, and dissolved CO2 among others with a weaker power. The implementation of osmolality measurement and its application in bioprocessing is also discussed.

  10. Gene Therapy Upstream Manufacturing, Scale-up And Best Practices 3/31/2021

    Gene therapies provide innovative options for treating patients, particularly where other traditional therapeutics have been ineffective. The industry continues to grow and mature from research to approved therapeutics. In this panel webinar series, hear directly from the authors of the eBook  "Insights on Successful Gene Therapy Manufacturing and Commercialization" on various topics related to gene therapy manufacturing and commercialization, the current state of the industry and how we can continue to advance these life-changing medicines.