In biopharmaceutical production, each instance where materials or products in development must be stored, handled, or transported presents a risk for breakage, contamination, and expensive product loss. In a modern, decentralized biopharmaceutical production line, materials and products must be kept frozen to ensure product safety, consistency, and shelf life. Because of these new realities, we face more production costs, logistics, speed, and complexity.

Bioproduction today has dramatically increased the value of product in each container. Production processes have been contracted out or may be taking place in different parts of the country or globe. At colder temperatures, containers have considerable limitations; traditional storage bottles are often more brittle at cold temperatures and can break easily, do not pack into containers or store in freezers efficiently and take longer to freeze and thaw due to their shape and volume. 

Entegris is in a unique position to help overcome these cold temperature challenges by offering assemblies designed for extreme cold and by partnering with qualified equipment manufacturers specializing in reliable, cold-chain containment. Let us help you gain control over your processes and reduce the potentially enormous financial risk to your valuable products. 


Aramus™ 2D single-use bags that provide high purity, exceptional compatibility, and increased safety for critical process fluids and final products are now available in custom shapes, sizes, and assembly configurations.

Our technology center has everything needed to make educated decisions about what freezing process and products best fit your needs.

PSTP series cartridge filters ensure reliable product processing featuring polypropylene components and a hydrophilic polyethersulphone (PES) membrane enabling economical and efficient use in various pharmaceutical applications.

PSTP series cartridge filters ensure reliable product processing enabling economical and efficient removal of particulate and colloidal contaminants in various pharmaceutical applications.

Made from high-quality stainless steel and heavy-duty plastic material, the freezing shells provide greater bulk drug substance (BDS) protection during handling, more consistent freezing/thawing, and reduced storage density.

Entegris solutions allow you to protect and store your high-value process solutions with reduced risk of product loss, contamination, and compromised quality. Expanding our portfolio further, we offer LN2 (liquid nitrogen) cassettes for use with Aramus™ single-use bag assemblies.

The utilization of single-use (SU) systems continues to grow, and so do the purity concerns of the SU components and their potential impact on high-value final products. From the high cost of product loss due to assembly failures at fill/finish, to the ever-increasing scrutiny from regulatory bodies, every angle requires protective measures. Now, Entegris brings a new level of assurance to your process. The Aramus™ single-use 2D bags are made of a high-grade, gamma-stable fluoropolymer, providing higher purity, greater compatibility, and increased safety for critical process fluids and final products.

Two of the most significant benefits to single-use bioprocessing over reusable manufacturing equipment are lower cost and simpler operation. And yet some processing steps, such as mixing, have not been able to realize these benefits. The Entegris mixing system is designed to maximize simplicity, ease-of-use, and affordability.

The Entegris microcarrier separation system is designed to ease the finance and complexity burdens of single-use systems while maximizing simplicity, ease of use, and affordability. This system facilitates a separation process through the use of a streamlined, single-use filter/mesh bag system and peristaltic pump; no other equipment is required.

Bringing the benefits of ultimate customization, fast design, and delivery to cell culture applications, Entegris offers the motion bioreactor bag.

What does “custom” mean for bioprocessing companies? Many system suppliers advertise their capability in customization but in reality, limit it to the interchange of components or lengths of tubing. This is helpful, but falls short of what many end users are looking for. With single-use systems, Entegris offers true customization to meet your exact process needs, fast.


Aramus 2D single-use bags in custom shapes, sizes, and assembly configurations to optimize your process and meet your most challenging requirements.

Protect your high-value fluids with Aramus 2D bag assemblies and reduce the risk of product loss, contamination, or compromised quality.


Entegris, Inc.

129 Concord Road

Billerica, MA 01821


Phone: 978 436 6500

Fax: 978 436 6735

Contact: Barry Westfall