SOLUTIONS

• Genome Engineering Platforms

  Leverage the latest genome editing technologies and our exclusive innovations for your mammalian cell line engineering project

   

• TARGATT™ RUO Hypo Plus Human iPSC

  Eliminating HLA expression limits T-cell recognition but can invite NK-cell attack. A hypoimmune iPSC line pairs B2M and CIITA knockouts with five immune-modulatory knock-ins to address both arms.

• iPSC Drug Discovery Platform

  An iPSC drug discovery platform delivering end‑to‑end genome engineering, differentiation, and GMP transition to generate biologically relevant human cell models for efficient discovery and translation.

• cGMP Cell Manufacturing

  Are you in need of an experienced and flexible GMP service provider that can assist you with the development and clinical manufacturing of your gene or cell therapy with expert CMC support?

• Master And Working Cell Banks, 24/7 Monitoring

  Master and working cell banks can be customized to your project needs for size, concentration, and quality in-process and release testing.

• iPSC Generation Services

  iPSC generation is a complex process of reprogramming adult somatic cells into a pluripotent, embryonic stem cell-like stage.

• Cell Line Engineering Services

  Go bigger, stay on target, and engineer the mammalian cell lines that get the job done.

• MAD7 Gene Editing

  A Class 2 Type V Cas9 nuclease, Mad7 is ideal for product development that relies on genome editing. 

• CRISPR/Cas9 And Cas9 Variants

  A quick overview of this industry-changing technology as well as the newer Cas9 variants that expand its use.

• S-SELeCT™ One-Step Large Knock-In Technology

  Simple, scalable genome engineering at the naturally occurring S-SELeCT™ safe harbor locus.

• iPSC Differentiated Cell Products

  At Applied StemCell, we specialize in producing high-quality differentiated cells from well-characterized normal iPSCs. Our cells offer the biorelevance of primary cells while eliminating the challenges associated with sourcing and variability across batches.

• iPSC Lines: iPSC Control Lines From Healthy Donors

  At Applied StemCell, we specialize in providing high-quality induced Pluripotent Stem Cell (iPSC) lines that are crucial for advanced research in stem cell biology and regenerative medicine. Our iPSC lines are designed to support cutting-edge research and therapeutic development.

• TARGATT™ CHO Cells: Rapid, Stable CHO Cell Generation For Bioproduction

  With our proprietary TARGATT™ technology for site-specific integration of large DNA fragments, we’ve developed a series of TARGATT™ “master” cell lines, including engineered CHO.

• TARGATT™ HEK293 Kits

  Accelerate cell line development for library creation and protein expression with efficient TARGATT™ large knock-in technology.

• TARGATT™ iPSC Kits

  Build cell-based models of disease and accelerate therapeutic development with TARGATT™ large knock-in technology in iPSCs.

• Discover Our iPSC Differentiated Cell Services

  iPSC-differentiated cell lines combine scalability and biorelevance, enabling precise disease modeling, drug screening, and regenerative research with customizable lineage-specific differentiation options.

• TARGATT™ Large Knock-In Technology

  TARGATT™ large knock-in technology enables rapid, efficient, and precise integration of large DNA fragments—up to 20 kb in a single reaction, more in nested reactions—into a specific intergenic locus.

• Go Bigger, Stay On Target, And Develop The Cell Lines That Get The Job Done

  Build the most relevant cell line for your studies with the ability to insert 20+ kb of DNA site specifically, in single copy, and at efficiencies approaching 100% after selection.

• A Hypoimmunogenic iPSC Platform Reprogrammed

  Accelerate your allogeneic development by starting with a hypoimmunogenic iPSC platform reprogrammed from CD34+ cord blood cells.

• TARGATT™ Hypo hiPSC Knock-In Kit

  Rapidly advance your allogeneic development with a hypoimmunogenic iPSC platform that has pre-built TARGATT™ large knock-in technology.