What Is Pre-Use, Post-Sterilization Integrity Testing (PUPSIT)?

Aseptic processing plays a central role in protecting the safety and quality of medicinal products, and sterile filtration is one of its most critical safeguards. Sterilizing-grade filters are used to remove potential contaminants before filling, but their performance must be verified through integrity testing. Pre-use, post-sterilization, and post-use testing each help confirm that a filter is structurally sound and has functioned as intended throughout the process. As global regulatory expectations continue to evolve, manufacturers are being asked to strengthen contamination control strategies and, where possible, implement pre-use, post-sterilization integrity testing (PUPSIT).

Learn how sterile filter integrity testing supports aseptic processing, reduces product risk, and helps manufacturers align with current guidance.