Using Computational Fluid Dynamics (CFD) To Design Scalable Bioreactor Processes

Scaling a bioreactor requires balancing several interconnected parameters, including power input, mixing time, oxygen transfer, and shear. Computational fluid dynamics (CFD), combined with experimental characterization, can provide a clearer view of how these conditions change as processes move between vessel sizes. Using Cytiva’s Xcellerex™ X-platform bioreactors as a case study, this presentation examines scalability across working volumes ranging from 250 mL to 2,000 L.

Gain practical insight into using modeling and experimental data together to evaluate bioreactor performance, compare key engineering parameters across scales, and support more informed scale-up decisions.