Newsletter | July 20, 2026

07.20.26 -- Upstream Decisions Influence Downstream Challenges

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Make confident process decisions—from preclinical to scale up.

Catch our process development virtual summit on demand and hear from experts across upstream analytics, purification, and advanced therapeutics. Watch one session or twenty. Click to explore all sessions.

FOCUS ON UPSTREAM MANUFACTURING

Upstream Decisions Influence Downstream Challenges

In this segment from the Bioprocess Online Live event, “The Levers And Tradeoffs That Drive Process Productivity,” panelists David Scherr, Ph.D. (AstraZeneca) and Vadim Klyushnichenko, Ph.D. (Calibr-Skaggs), answer the question, “What should developers be thinking about upstream to avoid downstream complications?” Klyushnichenko believes process-wide considerations like this begin earlier than cell line development at the product’s molecular construct itself.

Mobius® ADC Reactor Performance

Read about a family of single-use ADC reactors that has been developed to offer a safer and more efficient ADC production method than traditional mixing systems and meet the industry's growing needs.

The Power Of 3: How Triple Stack Incubators Can Help Optimize Your Lab

Maximize your lab’s efficiency without sacrificing space. Observe how triple-stack incubators help scale operations, run multiple experiments, and streamline workflows within a compact footprint.

Predicting The Performance Of Perfusion Media In A Continuous Bioreactor

Small-scale perfusion-mimic models can effectively predict media performance in continuous bioreactors to help optimize cell density, productivity, and scalability for CHO cell lines.

Rebalancing mAbs: From Depth Filter Dependence To Process Harmony

Learn how optimizing clarification workflows can reduce product loss and minimize buffer consumption by shifting primary workloads away from traditional high-capacity depth filtration systems.

Advancing Therapeutic Discovery With High-Throughput Electroporation

See how high-throughput electroporation streamlines genetic material delivery for cell therapy and drug discovery, offering speed, precision, and scalability across hard-to-transfect cell types.

iPSC Aggregate Culture In Bioreactors Equipped With 8-Blade Impellers

Controlled aggregation, oxygen management, and scalable workflows drive consistent iPSC expansion. Parallelized systems and precise parameter control improve reproducibility for faster optimization.

Innovations In Perfusion Bioprocessing

Gain valuable insight into the optimization and scalability of perfusion media and processes, driving progress in biotechnological processes for monoclonal antibody production.

Optimizing The Path To First-In-Human Clinical Trials: Design And De-Risk

Examine the ways to design and de-risk molecules, streamlining the path to GMP manufacturing and clinical trials, and case studies that provide insight into key activities.

From Gene Editing To NGS-Based T Cell Characterization

Gene-edited T cells targeting PD-1 and TIGIT are redefining approaches to cancer therapy. Explore how cell engineering and integrated genomic workflows uncover critical insights into T cell function.

Enhance Productivity And Reliability: Shaking Incubator Proactive Service

Regular preventive maintenance is essential for ensuring the longevity and optimal performance of your shaking incubator. Find out how this approach helps avoid costly downtime and protects your research.

UPSTREAM MANUFACTURING SOLUTIONS

Bring The Power Of Versatile Incubator Shakers To Your Lab - INFORS HT

Scale Your AAV Production With Peace Of Mind - Mirus Bio

Customized Skid For Large Production Scale - KNAUER

Transient Expression Platform - ATUM

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