Rebalancing mAb Clarification: From Depth Filter Dependence To Process Harmony

Depth filtration often accounts for product losses between 5% and 15% in monoclonal antibody production. As upstream titers climb, the operational weight of managing dozens of filter cartridges, massive buffer volumes, and extensive cleanroom time creates significant bottlenecks. Shifting the primary clarification workload to low-shear centrifugation protects product integrity while drastically reducing the demand on secondary polishing filters. This rebalanced approach minimizes the physical footprint of the harvest and simplifies logistics, from material ingress to waste disposal.

Transitioning away from filter-heavy workflows allows manufacturers to achieve yields above 90% and reclaim valuable facility time. Discover how to harmonize your clarification process by accessing the full article.