With an increasing number of biologic therapies being developed, selecting the best containment to store and transport these products is becoming more of a concern. Because the bulk substances used to make biologic therapies are usually stabilized by being deep frozen to temperatures between 40°C to 80°C, they need containers that work well at these low temperatures. The fact that many of these products are high value and produced in small batches means that even a single leak could be problematic.
When comparing containment systems for cold chain use, it is critical to understand all the factors that can affect performance. Although polymer bags are an excellent choice for this application, not all polymer films perform the same way, even if their specifications rate them for use at low temperatures. A full suite of application testing is necessary to determine whether a bag will hold up to all the rigors of handling and shipping at extremely cold temperatures.