The Upstream/Downstream Process Balancing Act

By Serena Fries Smith and Hunter Malanson

Early collaboration and open communication between upstream and downstream are crucial to ensure a consistent end-to-end bioprocess.

Traditionally, bioprocess development is split into “upstream” and “downstream” functional groups. There are individual challenges associated with the development of both pieces of the process, with upstream focused on producing quality product, and downstream on purifying it. While these two functions rely on each other to be fully successful, they frequently work in parallel – yet separately – to meet the aggressive timelines of the program. This approach may allow for some efficiencies during development, but if the two teams are not working together, it can also create problems.