The Effect Of Mixing Homogeneity In Retentate Vessel On TFF Membrane Performance

This study introduces a refined and comprehensive analytical method designed to improve the interpretation of tangential flow filtration (TFF) diafiltration performance profiles. By directly linking the results to the evolving concentration gradients within the retentate vessel, the method offers deeper insights into process dynamics. Central to this advancement is the Repligen single-use KrosFlo® RS 30 TFF system, whose innovative design ensures near-complete homogeneity of the feed solution—an achievement that sets it apart from conventional TFF vessels and supports reliable, efficient scale-up. Trial runs conducted under varied process conditions using the ½” ID assembly of the RS 30 system further validate its capabilities. The study emphasizes two key findings: the introduction of a novel approach to interpreting diavolume performance and the superior mixing efficiency of the Repligen tulip tank retentate vessel compared to traditional designs.

Explore how the Repligen KrosFlo RS 30 TFF system can elevate your filtration processes.