Single-Use Clarification Across Process Scales Via DynaSpin Centrifuges And The Harvest RC Clarifier Platform

As monoclonal antibody production scales, conventional two-stage depth filtration can create significant facility and workflow challenges. Higher harvest volumes and cell densities often require more filters, increasing footprint demands and complicating operations. For volumes above 2,000 L, single-use centrifugation can replace primary depth filtration, reducing the number of clarifying filters needed while preparing the harvest stream for downstream purification. An integrated approach combining DynaDrive Single-Use Bioreactors, the DynaSpin Single-Use Centrifuge, and targeted depth filtration and chromatographic clarification technologies provides a flexible path for managing larger, denser cultures.

Discover how these technologies can streamline harvest and clarification while addressing the practical constraints of large-scale mAb manufacturing.