Newsletter | October 15, 2025

10.15.25 -- Scaling From Process Development To Production With A High Density Adherent Cell Growth Platform

 

From Bench To Billions: Facilitating Scale-Up Of Adherent Cultures For Cell And Gene Therapies

 

Maintaining culture in adherent conditions at scale is possible with forethought into workflow integrations, automation, and platform choices in developing a manufacture-ready seed train for these powerful cultures. We explore what researchers should consider when they are creating a risk-mitigating adherent culture process for cell and gene therapy scale-up.

 

Demonstration Of Scalability For A Novel Fixed Bed Reactor Platform

A new FBR platform allows operators to use one technology, with a standardized workflow, for their process development, scale-up, and manufacturing processes. Explore data demonstrating scalability of the Ascent technology using a standard viral vector producing cell line (HEK-293T).

 

Highly Efficient Production Of Adeno-Associated Virus

This study evaluates the performance of a flexible, automated fixed bed reactor (FBR) system during AAV, comparing it with a similar FBR system and 2D cell culture controls.

 

Direct Inoculation From Cryopreserved Cell Banks Using An Automated FBR

The automated process steps of this fixed bed bioreactor (FBR) system facilitate ease of use and consistency, shortening seed train timelines, and increasing cell yield consistency. This makes direct inoculation from cryopreserved cell banks an attractive option for experiments, seed trains, or production batches.

 

SOLUTIONS

Ascent® Fixed Bed Reactor System 100

Unlock flexibility in cell therapy workflows. Harvest viable cells with >90% recovery, enabling seed train use and streamlining vessel-to-vessel transfer for downstream processes.

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Ascent® Fixed Bed Reactor System 5

This automated, perfusion-based bioproduction platform is designed for attachment-dependent cell processes, enabling streamlined workflows and viable cell recovery with high yields.

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