Application Note

Scale-up And Tech Transfer From 100 L SIP/CIP Vessel To The 300 L S.U.F.

By Jason D. Brown and Nephi Jones

Tech Transfer

With proven expertise and process knowledge, we effectively support product demonstrations in the field. A collaborative study with a new customer was undertaken with the objective of taking an existing, smaller preclinical E. coli process previously performed in stainless steel vessels and scaling it up quickly using the Thermo Scientific™ HyPerforma™ 300 L Single-Use Fermentor (S.U.F.) The following were key objectives for the study:

  1. Demonstrate equivalent growth and product yield at a larger scale.
  2. Identify any process steps or parameters that must be changed to accommodate tech transfer using single-use products.
  3. Demonstrate that various online analytics, such as pH, dissolved oxygen (DO), mass, foam, and mass spectrometer (MS) off-gas analysis, can be beneficial to workflows for disposables.
  4. Demonstrate that expanded data quality may improve outcomes and success in the decision-making process.
VIEW THE APPLICATION NOTE!
Signing up provides unlimited access to:
Signing up provides unlimited access to:
  • Trend and Leadership Articles
  • Case Studies
  • Extensive Product Database
  • Premium Content
HELLO. PLEASE LOG IN. X

Not yet a member of BioProcess Online? Register today.

ACCOUNT SIGN UP X
Please fill in your account details
Login Information
I'm interested in newsletter subscriptions.
ACCOUNT SIGN UP

Subscriptions

Sign up for the newsletter that brings you the industry's latest news, technologies, trends and products.

You might also want to: