Application Note

RoosterGEM™ Shines On Lentiviral Transduction Of T Cells

Source: RoosterBio

By Mary Doolin, PhD, & Jonathan Carson, PhD

T-cell iStock-1159808506

Genetic engineering is a cornerstone of the cell therapy field, upon which very successful and effective treatments like Kymriah and Luxturna are built. We need not look further than the examples of chimeric antigen receptor (CAR) T cells and genome-edited “neoTCR” cells. In these groundbreaking treatments, patient T cells are isolated and “reprogrammed” to express CARs or personalized T cell receptors (TCRs) that will recognize and bind to specific antigens, such as surface markers or HLA peptides that are highly selective for cancerous cells.

Learn more about RoosterBio's jack of all trades product RoosterGEM™, which has been shown to enhance lentiviral and AAV transduction of adherent primary cells like mesenchymal stromal/stem cells (MSCs), and even dramatically boost transient transfection of MSCs with mRNA.

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