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| Non-Affinity Approach to Fc-Fusion Purification | A two-step, non-affinity purification strategy offers a powerful alternative to traditional Protein A chromatography for Fc-fusion proteins. While Protein A remains a widely used method, its low-pH elution can result in protein denaturation and degradation. We present a two-step purification workflow with a weak anion exchange-hydrophobic resin, followed by a strong anion exchange resin. This process achieves high-purity, high-yield purification of EGFR:Fc fusion proteins, while preserving protein integrity. Watch now. |
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FOCUS ON DOWNSTREAM MANUFACTURING |
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| Unlock The Future Of Biotherapeutic Purification | Application Note | Ecolab, Purolite™ Resins | This novel CH1 binding resin addresses purification challenges with Fab fragments and bispecific antibodies. Learn how to simplify downstream workflows and support sustainable manufacturing. |
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DOWNSTREAM MANUFACTURING SOLUTIONS |
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A conversation with Jose Caraballo-Oramas, biopharma executive | The compendial 14-day sterility testing window exposes product and patient to numerous risks, but settling on a rapid alternative also presents its own set of challenges. | |
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| Connect With Bioprocess Online: |
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