Rapid Selection Of High-Performance CHO Basal And Feed Media With The High-Throughput Media Screening Service

Selecting the right basal and feed media combination is one of the most consequential and time-consuming decisions in upstream bioprocess development. For a CHO-S cell line producing a bispecific antibody, one development team needed a better-performing solution without abandoning their existing fed-batch process or blowing past a 12-week deadline.

Traditional screening methods couldn't meet that bar. By leveraging a high-throughput media screening approach, they evaluated 180 predefined media and feed combinations, narrowed the field to eight top candidates, and ultimately confirmed a winning condition that delivered a 38% titer increase and 26% higher peak viable cell density compared to their existing control. The process worked, and it worked on time.

See how a structured, data-driven screening workflow can compress timelines, reduce in-house burden, and surface the media combination your cell line actually needs.