Case Study

Rapid 200 Fold Scale-Up Of A Fed-Batch Bioreactor Process For A CHO Cell Line expressing a Mab

Bioprocessing

The client had performed preliminary bioreactor runs at the 0.5 scale with the CHO cell line and required a rapid 200 fold scale-up to the 100L bioreactor level with minimal process development. Time constraints dictated that only two-3L bioreactor evaluations could be performed prior to scale-up to the 100L bioreactor. To add to the challenge the clients’ 0.5L bioreactor system differed in design from the 3 and 100L bioreactor utilized for process development and scale-up. Read how a fed-batch bioreactor process of a CHO cell line was transferred from a client and scaled 200 fold with minimal process development evaluation and testing.

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