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FOCUS ON UPSTREAM MANUFACTURING |
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By Jack (Jie) Huang, MD, Ph.D., CSTEAM Biotechnology | The ability to produce billions of NK cells in a single production run represents a transformative shift in the economics and logistics of cell therapy. | |
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| An Introduction To Transfection Methods | Article | Lonza | This technical guide provides information on the most common methods of gene delivery and compares them to Nucleofection. Delve into their advantages, disadvantages, and ideal applications. |
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| Scaling Up An Upstream Process For Gene Therapies | Infographic | Cytiva | It's important to evaluate your starting point when scaling an upstream process. Review key considerations for deciding between adherent and suspension cells to optimize your process. |
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| A Comparative Study Of Cryopreservation Media | Application Note | By Ericka Castillo, Nanami Kadota, David De Leonardis, Brad Taylor, Ph.D., and Asma Ayari, Ph.D., Nucleus Biologics | This study compared two different cryopreservation mediums and the data highlights which is ideal for preserving the viability of different cell types, including Mesenchymal Stem and HEK-293 Cell Line. |
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| Best Practices For Multi-Use Bioreactor Sterilization | Application Note | Getinge | Review the results of studies into the optimal method for cleaning and sterilizing a multi-use bioreactor, headplate, tubing, vent filters, liquid media and filled liquid addition bottle. |
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| Rev-Up AAV Genome Production In Upstream Manufacturing | Application Note | By Becky Reese, Jennifer Swanson, Austin Storck and Laura Juckem, Mirus Bio | By increasing recombinant AAV titers, this AAV enhancer can help reduce upstream manufacturing costs and lower the cost per therapeutic dose. |
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| Multispecific molecules bring added complexity to downstream purification—think incorrect chain pairings, aggregation, fragmentation, and lower yields. Join Bioprocess Online Live as we explore how developers are addressing these challenges to achieve high purity and efficient processes. Gain insights into key considerations for downstream teams when designing purification strategies for these advanced biologics. Registration is free thanks to the support of Thermo Fisher Scientific. |
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UPSTREAM MANUFACTURING SOLUTIONS |
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