Application Note

Protein L Affinity Resin Is Ready To Move To Manufacturing

Source: Cytiva
Scientist Laboratory sample pipette GettyImages-1354172647

Protein L affinity chromatography resins are used for the capture of antibody Fabs, bispecifics, and other variants containing a kappa light chain. Although protein L affinity resins have been available for more than a decade, insufficient binding capacities and alkaline stability challenges have limited their use in productive manufacturing processes.

This study examines the dynamic binding capacities of the MabSelect™ VL resin from Cytiva, Capto™ L resin from Cytiva, TOYOPEARL® AF-rProtein L-650F resin from Tosoh Bioscience, and KanCap L affinity chromatography resin from Kaneka. Explore study results to discover which resin is the most suitable option for productive biomanufacturing processes.

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