Newsletter | December 3, 2025

12.03.25 -- Predicting Viral Clearance Through CHO-RVLP And MVM-Mock Viral Particles

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Watch the BioTitan Retention Device outperform cable ties under pressure

Watch the video to see the exceptional reliability of the Thermo Scientific™ BioTitan™ Retention Device in action. Learn how it outperforms traditional cable ties, helping ensure secure connections in single-use assemblies. You can integrate the BioTitan device into various single-use products, including bioprocess bags, bottles, and fluid transfer assemblies, and hardware consumables for use with Thermo Scientific™ equipment. Request free BioTitan sample kit to evaluate.

FOCUS ON DOWNSTREAM MANUFACTURING

Engineering Bacterial Vector-Based Immunotherapies With OS Therapies

By Better Biopharma

In this throwback episode of “Better Biopharma,” host Tyler Menichiello is joined by OS Therapies’ CEO, Paul Romness, and chief medical and scientific officer, Robert Petit, Ph.D. The three discuss the development and manufacturing of the company’s lead asset, OST-HER2, a Listeria-based immunotherapy for osteosarcoma.

Development Of RP Methods For The Analysis Of Synthetic Peptides

Webinar | Waters Corporation

Explore the expanding role of synthetic peptides in drug development and learn how advanced RP chromatography methods are vital for impurity profiling to ensure safety and efficacy.

Enhancing Viral Clearance Prediction And Process Optimization

Case Study | AGC Biologics

MockV technology enables early, in-house viral clearance assessment, helping biopharma developers improve process robustness, reduce costs, and enhance safety before GMP manufacturing begins.

Predicting Viral Clearance Through CHO-RVLP And MVM-Mock Viral Particles

Poster | By David Cetlin, Cygnus Technologies Inc.

Reduce the cost and complexity of viral clearance validation with non-infectious surrogates. Learn how CHO-RVLP and MVM-MVP enable safer, more efficient biopharmaceutical process development.

Considerations In Depth Filter Scale-Up

Webinar | Cytiva

Explore study findings aiming to assist process development scientists and engineers in understanding the structure of depth filter capsules, identifying key parameters for development, and more.

Carryover Analysis Through Two Consecutive Cell Culture Harvests

Application Note | By Brad Joines, Mike McManaway and William Barrett, Ph.D., W.L. Gore & Associates

Follow this ELISA testing that analyzes a protein capture device for carryover effects after consecutive cycling of two different cell culture harvests.

Handle Your Large-Scale Buffer Preparation Efficiently

Application Note | Repligen

Discover how to prepare 10x PBS using an innovative system to ensure scalable, efficient, and consistent buffer preparation for large-scale workflows.

DOWNSTREAM MANUFACTURING SOLUTIONS

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Sterile Filtration: Filter Sizing For Process Optimization - Entegris, Inc.

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A Solution Taking Single-Use Filtration To Manufacturing Scale - Cytiva

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The Next Evolution Of Droplet Digital PCR - Bio-Rad Laboratories, Inc.

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Purification Solutions For Resilience CDMO - Ecolab, Purolite™ Resins

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Webinar: Seal the Deal: Mastering Vent Integration in Medical Devices

Join W. L. Gore & Associates Application Specialist David Kunzig to explore the vital role of venting and microfiltration in life science applications—from drug delivery to diagnostics. Learn how vent orientation, welding techniques, and design choices impact system reliability. Through real-world visuals and a detailed case study, discover practical troubleshooting strategies to optimize performance and integration. Click here to learn more.

FOCUS ON FILL-FINISH

Orphan Drug Aseptic Fill Finish, Clinical Trials, And The Impact Of Advocacy

Article | Argonaut Manufacturing Services

Orphan drug development is a journey marked by challenges at every step. From patient recruitment to aseptic fill finish, overcoming hurdles is critical for bringing life-saving treatments to market.

FILL-FINISH SOLUTIONS

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Aseptic Filling Qualification Solutions - Cytiva

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The Future Of Glass Packaging Is Here - West Pharmaceutical Services, Inc.

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