Pre-Use Post Sterilization Integrity Testing (PUPSIT)

Pre-use post sterilization integrity testing (PUPSIT) is used to detect integrity defects in the sterilizing filter within a single-use assembly, known as filter flaw masking. This quality breach could have catastrophic consequences for the patient, so Avantor uses PUPSIT globally to reduce filter defects and contamination. This fact sheet explains how, when, and why PUPSIT should be used and how Avantor can help navigate the complexities of filter integrity testing.