Powering Results In Harvest And Clarification Process

As monoclonal antibody processes intensify, rising cell densities, titers, and solids loads can turn harvest and clarification into significant production bottlenecks. Integrating single-use centrifugation with chromatographic clarification can reduce the solids burden before filtration, helping manufacturers improve filter performance while lowering filter area, consumable demand, process-liquid usage, and facility footprint. Modeled results illustrate the potential for approximately 150% greater filter capacity, 50% lower water usage, and a 76% smaller process footprint compared with a conventional two-stage depth-filtration approach.

See how a scalable, closed workflow combining the Thermo Scientific™ DynaSpin™ Single-Use Centrifuge System and Harvest RC Chromatographic Clarifier Platform can simplify large-volume clarification.