Performance Evaluation Of A Single-Use Bioreactor (S.U.B.) For Perfusion Applications

Single-use (SU) bioreactors have been a key driver in the transformative shift toward SU technology in bioprocessing. With first-generation equipment developed for less intensive fed-batch production methods, technologies focused on supporting high-density perfusion cultures with greater oxygen demands are of pivotal importance. Originator bioreactor technology also demonstrated ergonomic shortcomings, complicating the daily-use operations for end users in the cleanroom space.

In a recent webinar, “Performance Evaluation of Thermo Scientific DynaDrive S.U.B. for Perfusion Applications,” professionals from Thermo Fisher and Merck & Co., Inc., Rahway, NJ, USA, known as MSD outside the United States and Canada, discussed data obtained from a performance evaluation of the Thermo Scientific™ DynaDrive™ Single-Use Bioreactor (S.U.B.). The DynaDrive S.U.B. is the latest advancement based on our history of proven innovation, offering superior performance to accommodate larger volumes as programs progress to commercialization. While progressive advances in media optimization and improved clone selection increase stress on continuous single-use systems, strategic enhancements to the DynaDrive S.U.B. are integrated to counter the perceived limitations. Coupled with best-in-class media hydration, hold tanks, and bioreactor control systems, a continuous bioprocessing workflow is established.