PAT: Out Of The Dark Ages

By Christopher D. Brown, chief product officer and co-founder, 908 Devices Inc.

The term "PAT" might evoke mixed feelings in the biopharma industry, but its potential to revolutionize process development is undeniable. Despite the initial hype and subsequent disillusionment, Process Analytical Technologies, coupled with the power of AI/ML, are poised for a resurgence. This renewed focus stems from the urgent need for efficient execution, consistent quality, and predictable scalability in biotherapeutic development. While traditional PAT tools like bioreactor monitoring have become commonplace, integrating advanced analytical instruments has proven challenging. The complexity of these instruments often necessitates specialized expertise, creating a bottleneck for process development scientists. To truly harness the power of PAT, we need a shift towards user-friendly, automated solutions that seamlessly integrate into the PD workflow and empower scientists with actionable information, not just raw data.

Continue reading to discover how democratizing PAT can unlock efficiency and innovation in biopharmaceutical process development.