09.09.26 -- Overcoming Recovery Challenges In AAV Production

Single-use virus filtration offers key strategic benefits beyond operational convenience, enabling faster time to market, scalable manufacturing, and flexible supply chains for biopharma production.

Metal-sensitive analytes often suffer from poor recovery and distorted peak shapes. Learn how inert hardware improves sensitivity and chromatographic performance for challenging analyses.

Evaluate surface treatments, scalability, and contamination risks to select the right adherent platform. Testing early ensures a seamless transition from benchtop to production.

For innovative treatments like CAR-T and stem cell transplants, optimal starting material is key. Understanding collection challenges and new solutions helps ensure the best foundation.

Move beyond general detection toward targeted risk assessment. Identify problematic impurities that impact drug stability and learn to standardize your analytical control strategies.

Explore strategies to maximize drug product recovery during sterile filtration, minimize hold-up volume, and reduce dilution after PUPSIT to ensure higher yield, improved efficiency, and less waste.

Take an in-depth look at a capture device designed to scale consistently by residence time. The data provided indicates the process can be transferred easily across LC systems.

As oligonucleotide-based drugs gain momentum in therapeutic development, refining their manufacturing processes through solutions like ion exchange chromatography (IEX) becomes crucial.

See how early integration of cell line engineering, process development, and analytics compressed a complex antibody program from DNA to drug substance bulk fill in just 8.5 months.

Gain insight into how automated, banded pH control uses dose-and-wait logic to limit overshoot, account for mixing and buffer effects, and maintain stable setpoints across changing fill volumes.

Adopting AI and robotics enhance sterility and regulatory compliance and enable real-time decision-making and reduce human-borne contamination, ensuring the safe production of complex therapies.

Thermal analysis reveals how particle size and morphology influence material interactions and stability. Discover how DSC and MDSC techniques uncover compatibility issues and guide better selection.