White Paper

Outstanding Sensitivity For Confident SPR Interaction Analysis

Source: Cytiva
doctor analyzes monoclonal antibodies GettyImages-1317916302

When you perform surface plasmon resonance (SPR)-based analyses with a high sensitivity instrument— you can also have greater data precision and better confidence in your results interpretation. Higher sensitivity enables you to:

  • work at the limit of kinetic, molecular weight and
  • concentration ranges
  • be more precise when measuring and studying
  • interactions involving low molecular weight analytes
  • better study unstable molecules like membrane proteins — optimization for high activity and high signal levels is generally not necessary
  • use lowest level of attached ligand to more accurately
  • measure on- and off-rates
  • characterize binding of antibodies without the
  • complicating effects of avidity

When analyzing interactions involving very small molecules in drug discovery, there is no lower limit in terms of molecular weight. Explore how previously borderline kinetic data can now be confidently accepted.

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