Oligonucleotide Manufacturing: End-To-End Solutions To Enable Large-Scale Processing

As the field of oligonucleotides rapidly grows, transitioning from lab research to large-scale processes presents significant challenges, particularly in unit operations. Cost-effective commercialization of RNA therapeutics demands ultra-high purity processing with sustainable yield. Addressing this need requires end-to-end solutions and a partner who can optimize processes across the entire value chain.

Solutions are available to enhance every step of oligonucleotide manufacturing, from upstream to downstream. For synthesis, this includes innovative, high-purity solvent delivery systems and specialty organophosphorous chemicals. Downstream processing—including cleavage, deprotection, purification, and isolation—can be optimized with single-use assemblies, corrosion-resistant fluid handling, and contamination control solutions. Furthermore, particle characterization tools can enable control for effective lipid nanoparticle (LNP) delivery.

Explore how to achieve ultra-high purity, high-yield processing for your oligonucleotide commercialization efforts.