Normal ("dead-end") Flow Filtration (NFF) is frequently required in the purification process fo biological fluids. Normal flow filtration (NFF) products increase process efficiency from early phase product development through to production by protecting downstream operations or by polishing final products.
The ULTA family of normal flow filtration (NFF) products is designed to support a wide range of biopharmaceutical liquid filtration applications. Cartridges and capsules are fully traceable with unique serial number integrity. A range of capsules and filter discs are also available for small volume processes as well as sample throughput characterization.
ReadyToProcess ULTA normal flow filter capsules are single-use filters designed for laboratory through process scale applications. Volumes range from a few milliliters to thousands of liters of solution. The filters provide prefiltration and sterilizing grade filtration for a wide range of biopharmaceutical solutions.
In NFF, the feed stream moves perpendicular to the membrane and purified liquid passes through the membrane. Membrane filters primarily retain matter due to size differences between the molecules and the pores in the membrane. Particulates and aggregates are retained in the pores or form a ‘filter cake’ that reduces flow and increases pressure over time. Generally, normal flow filters are used when clarification or bioburden reduction is desired in relatively low solid streams, such as during final polishing of a product.
Cross flow filtration vs. Normal flow filtration
Both technologies purify bioprocess solutions by removing contaminates with a fixed porous medium, yet each format has unique advantages. Generally, normal flow filters (NFF) are used where clarification and/or bio-burden reduction is desired in relatively low-solid streams, for protecting or enhancing downstream operations, or when final polishing is required to achieve sterility. Cross flow filters (CFF) are best suited for higher solids, more viscous feed solutions, and/or where concentration or purification of cells or target species is desired.
The guide below provides further information. Where functional needs overlap, a Cytiva Filtration Specialist can help you find the optimal configuration for your specific operation.