New Filtration Protocols Accelerate Viral Vector Development And Enhance Scale Up To Production

The optimism about gene therapy’s efficacy is driving research into new products that treat cancer and genetic and infectious diseases. An important part of this work has involved the development of viral vectors that can effectively transfer therapeutic genes into a patient’s systems.

Lentiviral vectors have been increasingly used as a tool for gene and cell therapies since they can stably integrate the genome in dividing and non-dividing cells. However, the development of efficient, fast, and robust processes that cope with the low stability of this virus is slowing down the clinical-to-market transition. Filtration products such as plates
and centrifugal spin devices are being introduced that can significantly speed up lentiviral vector research protocols.

In this brief, we will discuss how new filtration applications can accelerate viral vector workflows. We also will review an example where filtration technology is optimizing a scalable and GMP-compatible purification process for lentiviral vectors that works effectively from research and development through manufacturing.